discontinued

GTX30376 Mre11 antibody

See related secondary antibodies

Search for all "Mre11"

0.1 mg / €410.00

Quick Overview

Rabbit anti Human Mre11

GTX30376

Product Description for Mre11

Rabbit anti Human Mre11.
Product is tested for Western blot / Immunoblot.

Properties for Mre11

Product Category Primary Antibodies
Quantity 0.1 mg
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
A synthetic peptide, which represented a portion of human Meiotic Recombination 11 encoded within exon 3 (LocusLink ID 4361).
Application WB
Background The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions (1). This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity
Concentration 1 mg/ml
Storage Keep as concentrated solution, aliquot and store at 4
Format
State:
Liquid
Specificity
Specificity:
This product recognizes human Mre11. Other species have not been tested. Reactivity with mouse and rat is likely (28/30 residues of the peptide used for immunogen are identical to mouse and rat Mre11).

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