NB120-3381 MRP 6 antibody

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Rat anti Human MRP 6 M6II-31


Product Description for MRP 6

Rat anti Human MRP 6 M6II-31.
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for MRP 6

Product Category Primary Antibodies
Quantity 0.25 ml
Synonyms CFTR/MRP
Reactivity Hu
Applications C, ICC/IF, WB
Clonality Monoclonal
Clone M6II-31
Host Rat
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Bacterial fusion protein of human MRP 6, containing amino acids 764-964, spanning the putative 12th transmembrane region as well as predicted internal and external regions of the protein.
Background The human multidrug-resistance protein (MRP) gene family is composed of multiple members including MRP 1, MRP 2 or cMOAT, and four other homologous genes, called MRP 3, MRP 4, MRP 5, and MRP 6. The substrate range of MRP 6 has not been fully determined and the expression pattern of MRP 6 has only been studied at the mRNA level. Mutations in the MRP 6 gene are responsible for the connective tissue disorder Pseudoxanthoma elasticum (PXE). Human MRP 6 is a 190 - 200 kDa transmembrane protein that is related to the family of Multidrug Resistance related Proteins (MRP).
General Readings General references:Scheffer GL, et al., (2002) MRP6 (ABCC6) detection in normal human tissuesand tumors. Lab Invest. 2002 Apr;82(4):515-8.Bergen AA, et al., (2000) Mutations in ABCC6 cause pseudoxanthomaelasticum. Nat Genet. 2000 Jun;25(2):228-31.Scheffer, G.L., (2000) Specific detection of multidrug resistance proteinsMRP1, MRP2, MRP3, MRP5 and MDR3 p-glycoprotein with a panel ofmonoclonal antibodies. Cancer Research 60(18): 5269-77.
Tissue culture supernatant
Buffer System:
Tissue culture supernatant with 0.1% sodium azide and 1% BSA
Tissue culture supernatant
Cross-reacts with Human.Not yet tested in other species.

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