NB110-60484 MSH2 antibody

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Mouse anti Human MSH2 3A2B8C


Product Description for MSH2

Mouse anti Human MSH2 3A2B8C.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot, Paraffin Sections.

Properties for MSH2

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Purified
Reactivity Hu
Applications E, P, WB
Clonality Monoclonal
Clone 3A2B8C
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Ni-NTA purified recombinant human MSH2 expressed in E. Coli strain BL21 (DE3).
Isotype control AM03095PU-N, SM10P (for use in human samples)
Background MSH2 is a 100 kDa nuclear antigen and encodes a protein of 934 amino acids. The MSH2 gene is one of 4 known genes encoding proteins involved in the repair of mismatch nucleotides following DNA replication or repair. Mutations in the MSH2 gene contribute to the development of sporadic colorectal carcinoma. MSHS mutations are responsible for 50% of inherited non-polyposis colorectal (HNPCC). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process.
General Readings
  1. Papadopoulos, N. 1994. Science 263: 1625-1629.
  2. Palombo, F. 1994. Nature 367:417-418.
Storage Store at -20 degrees.
protein G purified
protein G purified

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