DM429 MSH6 antibody

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1 ml / €630.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Canine, Human, Mouse, Rat MSH6 44

DM429

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  • DM429

Product Description for MSH6

Mouse anti Canine, Human, Mouse, Rat MSH6 44.
Presentation: Supernatant
Product is tested for Frozen Sections, Immunoprecipitation, Western blot / Immunoblot, Paraffin Sections.

Properties for MSH6

Product Category Primary Antibodies
Target Category
Quantity 1 ml
Synonyms DNA mismatch repair protein Msh6, G/T mismatch-binding protein, GTBP, MutS-alpha 160 kDa subunit, p160
Presentation Supernatant
Reactivity Can, Hu, Ms, Rt
Applications C, IP, P, WB
Clonality Monoclonal
Clone 44
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P52701
Immunogen:
Synthetic human MSH6 peptide
GeneID:
2956
Application Immunoprecipitation.
Western Blot: 1/100-1/500.
Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: 1/25-1/50 in an ABC method (30 to 60 minutes at room temperature (requires high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining).
Immunohistochemistry on Frozen Sections.
Recommended Positive Control: Tonsil, colon carcinoma
Background An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time.
General Readings
  1. Frasno et al. Mod Pathol 11: 934, 1998.
  2. Schleger et al. Exp Cell Res 236: 418, 1997.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity Chromatography.
State:
Liquid purified Ig fraction containing Sodium Azide as preservative.
Supernatant
Specificity
Specificity:
MSH6 is a heterodimer of MSH2 binds to DNA containing G/T mismatches.
The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop.
Cellular Localization: Nuclear.
Species:
Human, Mouse, Rat and Dog.
Gene ID 2956

Accessory Products

Proteins and/or Positive Controls

Proteins for MSH6 (2 products)

Catalog No. Species Pres. Purity   Source  

MSH6

MSH6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

MSH6

MSH6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for MSH6 (1 products)

Catalog No. Species Pres. Purity   Source  

MSH6 Lysate

Western Blot: MSH6 Lysate [NBL1-13328] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for MSH6
  Novus Biologicals Inc.
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