TA326879 MSH6 antibody

MSH6 Rabbit Polyclonal Antibody

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0.1 mg / €335.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat MSH6

TA326879

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  • TA326879
  • TA326879

Product Description for MSH6

Rabbit anti Human, Mouse, Rat MSH6.
Presentation: Purified

Properties for MSH6

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms DNA mismatch repair protein Msh6, G/T mismatch-binding protein, GTBP, MutS-alpha 160 kDa subunit, p160
Presentation Purified
Reactivity Hu, Ms, Rt
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P52701
Immunogen:
Recombinant protein of human MSH6.
GeneID:
2956
Application WB 1:500 - 1:2000
IHC 1:50- 1:200
IF 1:20- 1:100
Background The D mismatch repair system (MMR) repairs post-replication D, inhibits recombition between nonidentical D sequences, and induces both checkpoint and apoptotic responses following certain types of D damage. MSH2 (MutS homologue 2) forms the hMutS-a dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-a is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins, and the Rad50-Mre11-NBS1 complex. Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world. Mutations in MSH6 have been shown to occur in glioblastoma in response to temozolomide therapy and to promote temozolomide resistance
Format
Purification:
Affinity purification
Buffer System:
Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Proteins for MSH6 (2 products)

Catalog No. Species Pres. Purity   Source  

MSH6

MSH6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

MSH6

MSH6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for MSH6 (1 products)

Catalog No. Species Pres. Purity   Source  

MSH6 Lysate

Western Blot: MSH6 Lysate [NBL1-13328] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for MSH6
  Novus Biologicals Inc.
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