NB110-74773 Mucolipin-3 antibody

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Rabbit anti Rat Mucolipin-3


Product Description for Mucolipin-3

Rabbit anti Rat Mucolipin-3.
Presentation: Serum
Product is tested for Frozen Sections, Paraffin Sections, Western blot / Immunoblot.

Properties for Mucolipin-3

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms Mcoln3
Presentation Serum
Reactivity Rt
Applications C, P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Swiss Prot Num:
A synthetic peptide as a part of rat Mucolipin 3 conjugated to immunogenic carrier protein was used as the immunogen.
Add. information Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. When reconstituting, glycerol (1:1) may be added for an additional stability.
Application immunohistochemistry, Western Blot, Immunohistochemistry and Western Blot, immunohistochemistry , Western Blot 1:300 to 1:3000
Background Mucolipin 3 belongs to a family of cation channel proteins. In mammals, the mucolipin family includes three members mucolipin 1, mucolipin 2, and mucolipin 3. Mutations in MCOLN1 and MCOLN3 have been associated with mucolipidosis type IV and the varitint-waddler mouse phenotype. In humans, MCOLN2 and MCOLN3 are candidate genes for hereditary and/or sporadic forms of neurosensory disorders. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Expressed in the cochlea; particularly in the inner and outer hair cells.; DISEASE: Defects in Mcoln3 are the cause of the varitin-waddler (Va) phenotype. Classical Va mice exhibit early-onset hearing loss, vestibular defects, pigmentation abnormalities and perinatal lethality. The phenotype varitin-waddler Jackcon (Va-J), which arose in a cross segregating for Va, is similar but less severe. SIMILARITY: Belongs to the transient receptor family, polycystin subfamily.
General Readings
  1. Strausberg R.L, et al. Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Whole antisera
Buffer System:
No Preservative
Whole antisera
Mucolipin 3.
Gene ID 308022

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