AM12083PU-N Muscleblind Proteins antibody

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Mouse anti Mammalia Muscleblind Proteins MBNL


Product Description for Muscleblind Proteins

Mouse anti Mammalia Muscleblind Proteins MBNL.
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Muscleblind Proteins

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms EXP35, EXP40, MBNL, MBNL1
Reactivity Mam
Applications ICC/IF, WB
Clonality Monoclonal
Clone MBNL
Host Mouse
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Full-length recombinant human MBNL expressed in E
Application Immunocytochemistry / Immunoflourescence (1/50 - 1/2,000).
Western blot (1/500 – 1/2,000).
Background Muscleblind was originally isolated following studies of Drosophila, since inactivation of the muscleblind (mbl) gene in this species resulted in defects in the development of muscles and the visual system. The Drosophila muscleblind protein contains 4 zinc finger nucleic acid binding motifs. These binding domains are about 26 amino-acids long, co-ordinate one zinc ion and bind RNA. Human homologues of the single Drosophila muscleblind gene were discovered from cDNA and genomic sequencing, but were also discovered as a result of experiments aimed at finding proteins which bind to polynucleotide repeated sequences. Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the 3' UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle.
General Readings
  1. Begemann G. et al. Development 124:4321-4331 (1997).
Storage Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
50% glycerol, 0.01% sodium azide
Liquid Ig fraction
Species Reactivity
Species reactivity (tested):
This antibody detects Muscleblind Proteins.

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