TA320027 MYCT1 (C-term) antibody

Rabbit Polyclonal MYCT1 Antibody

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Search for all "MYCT1"

0.1 mg / €371.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse, Rat MYCT1

Product Description for MYCT1

Rabbit anti Human, Mouse, Rat MYCT1.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Enzyme Immunoassay, Western blot / Immunoblot.

Properties for MYCT1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms MTLC, MTMC1, Myc target protein 1
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, ICC/IF, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Molecular weight 26 kDa
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q8N699
Immunogen:
17 amino acid synthetic peptide near the carboxy terminus of Human MYCT1 (AP55477CP-N)
GeneID:
80177
Property C-term
Add. information Blocking peptide available: AP55477CP-N
Application Western blot: 1-2 µg/ml. 
Positive Control: Rat lung tissue lysate.
Immunofluorescence: Start at 20 μg/ml.
Background MYCT1 was initially identified as a novel target of the c-Myc oncogene in myeloid cells. It is a widely expressed nuclear protein whose overexpression can promote apoptosis, alteration of morphology, enhancement of anchorage-independent cell growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation. MYCT1 binds to the promoters of several c-Myc-regulated genes and it has been suggested that the phenotypes seen in MYCT1-overexpressing cells are a result of the deregulation of these genes. RUNX1-ETO, a fusion protein made up of RUNX1 and ETO, is thought to deregulate the proliferation and responsiveness of human hematopoietic progenitor cells downstream of MYCT1.
Concentration 1.0 mg/ml
General Readings
  1. Yin X, Grove L, Rogulski K, Prochownik EV. Myc target in myeloid cells-1, a novel c-Myc target, recapitulates multiple c-Myc phenotypes. J Biol Chem. 2002 May 31;277(22):19998-20010. Epub 2002 Mar 21. PubMed PMID: 11909865.
  2. Rogulski KR, Cohen DE, Corcoran DL, Benos PV, Prochownik EV. Deregulation of common genes by c-Myc and its direct target, MT-MC1. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18968-73. Epub 2005 Dec 19. PubMed PMID: 16365299. (Free PMC Article available, 5 images available)
  3. Liddiard K, Burnett AK, Darley RL, Tonks A. RUNX1-ETO deregulates the proliferation and growth factor responsiveness of human hematopoietic progenitor cells downstream of the myeloid transcription factor, MYCT1. Leukemia. 2012 Jan;26(1):177-9. doi: 10.1038/leu.2011.188. Epub 2011 Jul 29. PubMed PMID: 21799513. (Free PMC Article available, 3 images available)
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% Sodium Azide as preservative
State:
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Mouse, Rat.
Specificity
Specificity:
Tthis antibody will detect both isoforms (at least two isoforms of MYCT1 are known to exist).

Accessory Products

Proteins and/or Positive Controls

Positive controls for MYCT1 (2 products)

Catalog No. Species Pres. Purity   Source  

MYCT1 Lysate

Western Blot: MYCT1 Lysate [NBL1-13418] - Western Blot experiments.  Left-Control; Right -Over-expression Lysate for MYCT1.
  Novus Biologicals Inc.

MYCT1 overexpression lysate

MYCT1 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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