NB100-94365 MyD88 antibody

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Rabbit anti Human, Mouse MyD88

Product Description for MyD88

Rabbit anti Human, Mouse MyD88.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for MyD88

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Hu, Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Rabbit anti-MyD88 (IN) polyclonal antibody was raised against a peptide corresponding to amino acids 233 to 248 of human MyD88 (5), which differ from those of mouse by two amino acids.
Application Western Blot, This polyclonal antibody can be used for detection of MyD88 by Western blot at 1:500 to 1:1000 dilution. Whole cell lysate from Jurkat cells can be used as positive control and an approximately 35 kDa band can be detected. It is human and mouse reactive., Western Blot 1:500-1:1000,
Background The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kappaB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
0.02% Sodium Azide
IgG purified
Human, Mouse

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