discontinued

BM018 Myelin Basic Protein (MBP) antibody

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0.2 mg / €300.00

Quick Overview

Mouse anti Bovine, Guinea Pig, Human, Rabbit, Sheep Myelin Basic Protein (MBP) V/h1

BM018

Product Description for Myelin Basic Protein (MBP)

Mouse anti Bovine, Guinea Pig, Human, Rabbit, Sheep Myelin Basic Protein (MBP) V/h1.
Presentation: Purified
Product is tested for Enzyme Immunoassay.

Properties for Myelin Basic Protein (MBP)

Product Category Primary Antibodies
Quantity 0.2 mg
Presentation Purified
Reactivity Bov, GP, Hu, Rb, Sh
Applications E
Clonality Monoclonal
Clone V/h1
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
N-terminal fragment of human MBP (residues 1-118) produced by BNPS-skatole cleavage of pure human MBP, injected coupled to BSA using carbodiimide.

Format: This antibody is supplied as liquid, Protein A affinity purified IgG in PBS pH 7.2 with sodium azide as preservative.
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application ELISA. RIA. Other applications not tested. Optimal dilutions of this antibody are dependent on conditions and should be determined by the user.
Concentration conc. Lot specific
General Readings Elfman et al (1986) J.Neurochem. 46 509-515
Storage Aliquot an
Format
State:
Purified
Specificity
Specificity:
A group of 7 (or more) proteins produced from a single gene by alternate splicing found in central and peripheral nervous system myelin. The major basic protein (MBP) has long been of interest because it is the antigen, that, when injected into an animal, elicits a cellular immune response that produces the CNS autoimmune disease called experimental allergic encephalomyelitis (EAE), a T-lymphocyte mediated disease due to delayed-type hypersensitivity; though each species appears to respond to a different fragment of the 170 amino acid polypeptide.  In the peripheral nervous system, myelin basic protein 18.5 kD is often referred to as the P1 protein. Myelin basic protein (MBP) isoforms (isoforms 4-14) are with PLP the most abundant protein components of the myelin membrane in the CNS and are involved in formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis.  Isoforms 1-3/Golli-MBPs may have a role in the early developing brain long before myelination, perhaps as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells.  Differential splicing and post-translational modifications give a wide spectrum of isomers. Myelin basic protein is expressed in oligodendrocytes, myelin of white matter in the brain and spinal cord and in peripheral nerves. It is expressed less abundantly in grey matter.Recognizes predominantly residues 92-118. Reacts with pure MBP from sheep, rabbit, guinea-pig, and bovine sources.

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