AM32304PU-N Myeloid specific antigen antibody

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Mouse anti Human Myeloid specific antigen BM-1


Product Description for Myeloid specific antigen

Mouse anti Human Myeloid specific antigen BM-1.
Presentation: Purified
Product is tested for Paraffin Sections, Frozen Sections.

Properties for Myeloid specific antigen

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Myeloid Marker
Presentation Purified
Reactivity Hu
Applications C, P
Clonality Monoclonal
Clone BM-1
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Isotype control AM03095PU-N, SM10P (for use in human samples)
Application Immunohistochemistry on Frozen Sections.
Immunohistochemistry on Paraffin Embedded Tissue Sections.
Background BM-1 antigen is a 183 kD myeloid-specific-DNA-binding protein which is expressed in myeloid cells, including myeloid precursors and mature granulocytes. It is also expressed in chronic myeloid leukemia (CML) and M2 and M3 acute myeloid leukemias (AML) as well as myelomonocytic leukemias, but not in T, B, NK and other non-hematopoietic cells. The biological function of this antigen is not clear, although it has been proposed that BM-1 may play a role in the differentiation of myeloid cells.
Concentration 0.1 mg/ml
General Readings
  1. Epstein AL; Samoszuk M; Stathopoulos E; Naeve GS; Clevenger CV; Weil S; Marder RJ. Blood, 1987, 70(4):1124-30.
Storage Store the antibody undiluted at 2-8°C.
Shelf life: one year from despatch.
Buffer System:
0.05% Sodium Azide
Liquid purified IgG fraction
Species Reactivity
Species reactivity (tested):
BM-1 is reactive in B5 fixed, Paraffin Embedded tissue sections to Human myeloid cells and derived malignancies. 
The antibody reacts with a 183,000 Dalton cytoplasmic antigen with DNA- binding characteristics which is expressed in most myeloid precursor cells and myeloid leukemia's. It’s positive on myeloid precursors in bone marrow but lymph nodes are negative.
Tissue granulocytes are positive as well as scattered cells in peripheral cortex and interlobular septae of adult and fetal thymus.
Portal regions of fetal liver (18 weeks) are also positive. 
Identification of M2 and M3 AML, of CML and CMMol and granulocytic sarcomas with Immunohistochemistry in both Frozen and Paraffin Sections.

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