discontinued

AP33259PU-N Myosin heavy chain antibody

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0.1 ml / €310.00

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Rabbit anti Human, Rat Myosin heavy chain

AP33259PU-N

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  • AP33259PU-N

Product Description for Myosin heavy chain

Rabbit anti Human, Rat Myosin heavy chain.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence.

Properties for Myosin heavy chain

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Aff - Purified
Reactivity Hu, Rt
Applications ICC/IF
Clonality Polyclonal
Host Rabbit
Isotype IgG
Molecular weight 223 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Recombinant.
Application Immunofluorescence staining: 1/100-1/400.
Background Myosin heavy chain is an actin-based motor protein with an approximate molecular weight of 223 kD. Myosin heavy chain can be split into 1 light meromysin and 1 heavy meromysin chain (and further into 2 globular subfragments and 1 rod-shaped subfragment). This protein is highly expressed in muscle. Motor proteins that convert chemical energy derived from ATP hydrolysis into mechanical force that drives motile processes such as cytokinesis, vesicular transport, and cellular locomotion. Myosin heavy chain is modified by acetylation in cysteine residues in the S1 domain for myosin ATPase activity. Muscle myosin is a hexameric protein consisting of 2 heavy chain subunits and 2 alkali light chain subunits and 2 regulatory light chain subunits that forms filaments. 
Structure: Actin-based motor protein, approximately 223 kD. Myosin heavy chain can be split into 1 light meromysin and 1 heavy meromysin chain (and further into 2 globular subfragments and 1 rod-shaped subfragment).
Distribution: Highly expressed in muscle.
Function: Motor proteins that convert chemical energy derived from ATP hydrolysis into mechanical force that drives motile processes such as cytokinesis, vesicular transport, and cellular locomotion.
Regulation: Cysteine residues in the S1 domain are alkylated for myosin ATPase activity.
Modification: Alkylation.
Interaction: Muscle myosin is a hexameric protein consisting of 2 heavy chain subunits and 2 alkali light chain subunits and 2 regulatory light chain subunits.
General Readings
  1. Weiss A, et al. 1999. P. Natl. Acad. Sci. USA 96:2598.
  2. Schiaffino S, Reggiani C. Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev. 1996 Apr;76(2):371-423. PubMed PMID: 8618961.
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Antigen Affinity Chromatography
Buffer System:
PBS, pH 7.2
Preservatives:
0.09% Sodium Azide
Stabilizers:
50% Glycerol
State:
Liquid purified IgG fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, Rat.
Specificity
Specificity:
This antibody reacts against 1960 aa length Myosin heavy chain.

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