AP06320PU-N Na+ channel protein (pan) antibody

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0.1 mg / €350.00
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Rabbit anti Human, Mouse, Rat Na+ channel protein

AP06320PU-N

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  • AP06320PU-N

Product Description for Na+ channel protein

Rabbit anti Human, Mouse, Rat Na+ channel protein.
Properties: (pan)
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot, Paraffin Sections.

Properties for Na+ channel protein

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Sodium channel protein brain pan, Sodium channel protein pan, Voltage-gated sodium channe pan
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Molecular weight ~ 230 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide, corresponding to amino acids 1470-1520 of Human SCN5A.
Property pan
Application Western blot: 1/500-1/1000.
Immunohistochemistry on paraffin sections: 1/50-1/200.
Immunofluorescence: 1/50-1/200.
Background Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel’s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
Concentration 1.0 mg/ml
Product Citations
Purchased from Acris:
  1. Pasham V, Pathare G, Fajol A, Rexhepaj R, Michael D, Pakladok T, et al. OSR1-sensitive small intestinal Na+ transport. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 1;303(11):G1212-9. doi: 10.1152/ajpgi.00367.2011. Epub 2012 Sep 27. PubMed PMID: 23019198.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity Chromatography using epitope-specific immunogen.
Buffer System:
Phosphate buffered saline (PBS), pH~7.2
Preservatives:
0.05% Sodium Azide
State:
Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Aff - Purified
Species Reactivity
Species reactivity (expected):
Mouse and Rat.
Species reactivity (tested):
Human.
Specificity
Specificity:
This antibody detects endogenous levels of Sodium Channel-pan protein.
(region surrounding Lys1493)

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