TA306179 NADE / BEX3 antibody

Rabbit Polyclonal NADE Antibody

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Search for all "NADE / BEX3"

0.1 mg / €371.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse NADE / BEX3

TA306179

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  • TA306179

Product Description for NADE / BEX3

Rabbit anti Human, Mouse NADE / BEX3.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for NADE / BEX3

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Brain-expressed X-linked protein 3, DXS6984E, NGFRAP1, p75NTR-associated cell death executor
Presentation Purified
Reactivity Hu, Ms
Applications E, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q00994
Immunogen:
NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE.
GeneID:
27018
Add. information Blocking peptide available: AP30573CP-N
Application ELISA.
Western blot: 0.5 to 2 μg/ml. Despite its predicted molecular weight, NADE migrates at ~23 kDa in SDS-PAGE.
Immunohistochemistry on paraffin sections.
Background The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF) (1 for review). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR (2). Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed (5). Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells (3), NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage (4).
General Readings
  1. Gentry JJ, Barker PA, Carter BD. The p75 neurotrophin receptor: multiple interactors and numerous functions. Prog Brain Res. 2004;146:25-39. PubMed PMID: 14699954.
  2. Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, et al. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J Biol Chem. 2000 Jun 9;275(23):17566-70. PubMed PMID: 10764727.
  3. Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, et al. Characterization of three abundant mRNAs from human ovarian granulosa cells. DNA Cell Biol. 1990 Sep;9(7):479-85. PubMed PMID: 2171551.
  4. Yi JS, Lee SK, Sato TA, Koh JY. Co-induction of p75(NTR) and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat. Neurosci Lett. 2003 Aug 21;347(2):126-30. PubMed PMID: 12873743.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Ion exchange chromatography
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Purified
Species Reactivity
Species reactivity (tested):
Human, mouse
Specificity
Specificity:
This antibody detects NADE / BEX3.

Accessory Products

Proteins and/or Positive Controls

Proteins for NADE / BEX3 (4 products)

Catalog No. Species Pres. Purity   Source  

NADE / BEX3

NADE / BEX3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

NADE / BEX3

NADE / BEX3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

NADE / BEX3

NADE / BEX3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

NADE / BEX3

NADE / BEX3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for NADE / BEX3 (4 products)

Catalog No. Species Pres. Purity   Source  

NGFRAP1 293T Cell Transient Overexpression Lysate(Denatured)

NGFRAP1 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

NGFRAP1 overexpression lysate

NGFRAP1 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

NGFRAP1 overexpression lysate

NGFRAP1 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

NGFRAP1 overexpression lysate

NGFRAP1 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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