NB100-56794 Nap-1 antibody

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Rabbit anti Human Nap-1


Product Description for Nap-1

Rabbit anti Human Nap-1.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay.

Properties for Nap-1

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications E
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

This antibody was developed against a synthetic peptide corresponding to amino acids 196-204 (P1290) and amino acids 332-346 (P1291) of human Nap-1.
Background . Often times, multiple samples will be included, differing in the amino acid sequence used to raise the immune sera. NF-kB (nuclear factor kB) regulates the expression of a large number of genes that play critical roles in apoptosis, viral replication, tumorigenesis, various autoimmune diseases and inflammation (1). NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. IkB proteins are phosphorylated by IkB kinase (IKK) complex. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Five members of IKK family, IKKa, IKKb, IKKg, NAK/TBK/T2K, and IKKi contribute to the activation of NF-kB dependent gene expression. NAP1 (NA-associated protein 1) is a recently identified protein that interacts with NAK and IKKi. NAP1 induces oligomerization of NAK. NAK-NAP1 complex alone can activate NF-kB byphosphorylating Serine 536 of the p65 subunit of NF-kB.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein G purified
Buffer System:
Sodium Azide
protein G purified
Aff - Purified
Researchers are encouraged to optimize dilution for their specific testing.

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