AM05280PU-N Natural Killer Cell Receptor-P1 antibody

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0.1 mg / €360.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Mouse Natural Killer Cell Receptor-P1 1C10


Product Description for Natural Killer Cell Receptor-P1

Mouse anti Mouse Natural Killer Cell Receptor-P1 1C10.
Presentation: Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot, Flow Cytometry.

Properties for Natural Killer Cell Receptor-P1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Klrb1c NKR-P1, NKRP1
Presentation Purified
Reactivity Ms
Applications F, IP, WB
Clonality Monoclonal
Clone 1C10
Host Mouse
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized (BALB/c X C57BL/6)F1 (CbyB6F1) lymphokine-activated killer (LAK) cells and mouse myeloma cell line.
Application Western Blot (1-5 µg/ml).
Background Natural Killer (NK) cells are large, granular lymphocytes found primarily in peripheral blood, where they make up about 10% of the lymphocyte population. Their function is to defend against certain types of tumor cells and virally infected cells. When triggered, the cells release cytotoxic granules which induce either apoptosis or necrosis in the target cell. There are known to be two sets of cell surface receptor on NK cells which recognize target cells with opposing functions. One set, of which an example is NKR-P1 receptors, trigger cytokine release and cell cytotoxicity and the other set, of which Ly49A is an example, inhibit cytokine release. These receptors bind with MHC class I molecules on the surface of healthy cells which inhibits the release of cytokines. In virally infected or cancerous cells, class I MHC molecules are not expressed, inducing the release of cytokine. An activation signal is known to exist, however the mechanics of this signal are not very well understood.
Concentration Lot specific
General Readings
  1. Kung SK, Su RC, Shannon J, Miller RG. The NKR-P1B gene product is an inhibitory receptor on SJL/J NK cells. J Immunol. 1999 May 15;162(10):5876-87. PubMed PMID: 10229823.
  2. Gardiner, C.M. Natural killer cells. Curr. Biol. 1999, 9, R716.
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Buffer System:
PBS containing 0.08% Sodium Azide as preservative.
Liquid purified IgG fraction.
This antibody recats with NKR-P1 receptors and induces release of cytokine in SJL/J NK cells. (Ref.1)

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