SM079FT NC1.1 antibody

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Mouse anti Mouse NC1.1 IC4


Product Description for NC1.1

Mouse anti Mouse NC1.1 IC4.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for NC1.1

Product Category Primary Antibodies
Quantity 25 µg
Synonyms Natural Cytotoxix Cells
Presentation FITC
Reactivity Ms
Applications F
Clonality Monoclonal
Clone IC4
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Spleen cells from CBA mice. Spleen cells from immunised CE mice were fused with cells of the mouse NS-I myeloma cell line.
Application Flow Cytometry: Use 10 µl of neat antibody to label 10 µl of 10e6 cells in 100 µl
Background NC1.1 is a 45kD cell surface antigen. Natural cytotoxic cells represent a small subset of cells with cytotoxic activity against certain tumour cells in functional assays.
Concentration 0.1 mg/ml
General Readings
  1. Smart YC, Stevenson KL, Farrelly ML, Brien JH, Burton RC. Production of a monoclonal allo-antibody to murine natural cytotoxic cells. Immunol Cell Biol. 1990 Aug;68 ( Pt 4):277-84. PubMed PMID: 2249875.
  2. Smart YC, Tooney PA, Farrelly ML, Brien JH, Burton RC. Natural cytotoxic cells and tumour surveillance in vivo. Eur J Cancer. 1990;26(8):863-4. PubMed PMID: 2145924.
  3. Smart, Y.C. et al. (1992) Correlation of growth of tumours in NC-cell depleted mice with NC- and NK-cell mediated lysis in vitro. Int. J. Cancer 50: 817-821.
  4. Brien, J.H. et al. (1994) Phenotype and morphology of murine NC1.1+ natural cytotoxic cells. Immunol. Cell. Biol. 72: 161-168.
  5. Holmgreen SP, Wang X, Clarke GR, Noltorp RS, Roberts TK, Burton RC, et al. Phosphorylation of the NC-1.1 receptor and regulation of natural cytotoxicity by protein kinase C and cyclic GMP-dependent protein kinase. J Immunol. 1997 Mar 1;158(5):2035-41. PubMed PMID: 9036946.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Fluorescein Isothiocyanate Isomer 1
Affinity Chromatography on Protein G.
Buffer System:
PBS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
Liquid purified IgG fraction.
This antibody recognises an alloantigen designated NC1.1 expressed by murine natural cytotoxic cells.
The IC4 monoclonal antibody has been shown to block substantially NC cells activity in vivo and in vitro.
This antibody recognises the NC1.1 alloantigen in CBA, C57BL/6, BALB/c and NZB mice, but not in CE or DBA/2 mice.

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