NB120-2958 Nck antibody

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Rabbit anti Human, Mouse, Rat Nck


Product Description for Nck

Rabbit anti Human, Mouse, Rat Nck.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.

Properties for Nck

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu, Ms, Rt
Applications ICC/IF, IP, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant full length protein (Human).
Background Nck is a highly conserved protein that has one SH2 and three SH3 domains. It is ubiquitously expressed in mammalian tissues. Nck is phosphorylated on tyrosine, serine, and threonine residues in response to stimulation by EGF and PDGF. Nck has been proposed to function as anadaptor protein by coupling protein tyrosine kinases to signaling pathways that lead to cell proliferation. Overexpression of Nck results in transformation of NIH 3T3 cells.
General Readings General / background references:Kitamura Y et al. Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac. Biochem J 322 (Pt 3):873-8 (1997). PubMed PMID: 9148763
Lawe DC et al. The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68. Oncogene 14:223-31 (1997). PubMed PMID: 9010224
Birge RB et al. SH2 and SH3-containing adaptor proteins: redundant or independent mediators of intracellular signal transduction. Genes Cells 1:595-613 (1996). PubMed PMID: 9078388
Protein A purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Protein A purified
Cross-reacts with Human, Rat and Mouse.Not yet tested in other species.

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