NB120-3215 Nck antibody

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0.5 ml / €420.00

Quick Overview

Mouse anti Human Nck NC-20 (same as 20B-1H9)


Product Description for Nck

Mouse anti Human Nck NC-20 (same as 20B-1H9).
Presentation: Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for Nck

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu
Applications IP, WB
Clonality Monoclonal
Clone NC-20 (same as 20B-1H9)
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant full length protein (Human).
Background Nck is a highly conserved protein that has one SH2 and three SH3 domains. It is ubiquitously expressed in mammalian tissues. Nck is phosphorylated on tyrosine, serine and threonine residues in response to stimulation by EGF and PDGF. Nck has been proposed to function as an adaptor protein by coupling protein tyrosine kinases to signaling pathways that lead to cell proliferation. Over-expression of Nck results in transformation of NIH 3T3 cells.
General Readings General / background references:Kitamura Y et al. Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac. Biochem J 322 (Pt 3):873-8 (1997). PubMed PMID: 9148763
Birge RB et al. SH2 and SH3-containing adaptor proteins: redundant or independent mediators of intracellular signal transduction. Genes Cells 1:595-613 (1996). PubMed PMID: 9078388
Protein G purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Protein G purified
Cross-reacts with Human.Not yet tested in other species.

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