NB120-5800 NCoR2 antibody

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Rabbit anti Human, Mouse NCoR2


Product Description for NCoR2

Rabbit anti Human, Mouse NCoR2.
Presentation: Aff - Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for NCoR2

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu, Ms
Applications IP, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Purified His-tagged fusion protein, corresponding to amino acids 1302-1495 of Human NCoR2.
Background Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR) are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.
Concentration 1 mg/ml
General Readings General / background references:Ordentlich P et al. Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci U S A 96:2639-44 (1999). PubMed PMID: 10077563
Li H et al. Characterization of receptor interaction and transcriptional repression by the corepressor SMRT. Mol Endocrinol 11:2025-37 (1997). PubMed PMID: 9415406
Immunogen affinity purified
Buffer System:
Preservative: 0.05% Sodium AzideConstituents: PBS, 1mg/ml BSA
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human and Mouse (see review).Not yet tested in other species.

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