AM10204SU-N Ne acetyl lysine antibody

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Mouse anti Ne acetyl lysine 11A1

Product Description for Ne acetyl lysine

Mouse anti Ne acetyl lysine 11A1.
Presentation: Ascites
Product is tested for Frozen Sections, Enzyme Immunoassay, Western blot / Immunoblot.

Properties for Ne acetyl lysine

Product Category Primary Antibodies
Quantity 0.2 ml
Presentation Ascites
Applications C, E, WB
Clonality Monoclonal
Clone 11A1
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Nε acetyl lysine

ELISA: 1/5000-1/50000.
Western Blot: 1/500-1/5000.
Immunohistochemistry: 1/500-1/5000.

Background the nucleus, DNA is tightly packed into nucleosomes generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation. The reversible lysine acetylation of histones and non-histone proteins plays a vital role in the regulation of many cellular processes including chromatin dynamics and transcription, gene silencing, cell cycle progression, apoptosis, differentiation, DNA replication, DNA repair, nuclear import, and neuronal repression. More than 20 acetyltransferases and 18 deacetylases have been identified so far, but the mechanistic details of substrate selection and site specificity of these enzymes remain unclear. Over 40 transcription factors and 30 other nuclear, cytoplasmic, bacterial, and viral proteins have been shown to be acetylated in vivo.

Prior to reconstitution store the antibody at -20°C.
Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Lyophilized powder
Restore in distilled water.
Reacts with the Nε acetyl lysine, N-acetyl lysine and acetylated histones.
Does not cross react with either propionyl lysine or butyryl lysine.
The ability of this antibody to fix complement is unknown.

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