NBP1-44450 Nephrin antibody

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Rabbit anti Human Nephrin EPR2883Y


Product Description for Nephrin

Rabbit anti Human Nephrin EPR2883Y.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for Nephrin

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms CNF antibody, NEPHRIN antibody, NPHN antibody, anti-CNF antibody, anti-NEPHRIN antibody, anti-NPHN antibody, anti-NPHS1 antibody
Presentation Purified
Reactivity Hu
Applications WB
Clonality Monoclonal
Clone EPR2883Y
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Swiss Prot Num:
A synthetic peptide corresponding to residues surrounding tyrosine 1176 and 1193 of mouse Nephrin was used an immunogen. This antibody detects both Nephrin phosphorylated on tyrosines 1176 and 1193 as well as non-phosphorylated Nephrin.
Isotype control PP501P
Background Nephrin is a member of the immunoglobulin family of cell adhesion molecules that localizes to opposing sites of the secondary foot processes formed by podocytes, a specialized epithelial cell that ensures size- and charge-selective ultrafiltration. The human nephrin gene maps to chromosome 19q13.1 and encodes a 1,241 amino acid protein that contains a transmembrane domain, 8 Ig-like modules, and 1 fibronectin III-like module. Nephrin is expressed in embryonic and adult kidneys and localizes to glomerular podocytes and the glomerular slit diaphragm. Nephrin stimulates mitogen-activated protein kinases and is enhanced by podocin, which binds to the cytoplasmic tail of nephrin. A293 cells treated with Phorbol-12-myristate-13-acetate can upregulate nephrin, suggesting that protein kinase C is part of an intracellular signalling system, which regulates nephrin.
Storage Store at -20C. Avoid freeze-thaw cycles.
IgG purified
Buffer System:
50mM Tris-Glycine [pH 7.4] with 0.15M NaCl, 40% Glycerol and 0.05% BSA
Gene ID 54631

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