NB600-896 Nesprin antibody

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Rabbit anti Human Nesprin


Product Description for Nesprin

Rabbit anti Human Nesprin.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Nesprin

Product Category Primary Antibodies
Quantity 0.05 ml
Presentation Aff - Purified
Reactivity Hu
Applications C, ICC/IF, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide: GRSTPNRQKTPRGKC, corresponding to amino acids 3212-3226 of Human Nesprin.
Application IHC-FR, IF, WB
Background There are two genes encoding members of a new family of type II integralmembrane proteins. Both are ubiquitously expressed, and tissue-specificalternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus.These proteins are called Nesprin l and 2 for nuclearenvelope spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as "dystrophins of the nucleus" to maintain nuclear organization and structural integrity.
General Readings General / background references:Zhang Q et al. Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues. J Cell Sci 114:4485-98 (2001). PubMed PMID: 11792814
Immunogen affinity purified
Buffer System:
Constituents: PBS
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human.Not yet tested in other species.

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