discontinued

AM50006PU-N Neuregulin 1 (Beta-3) antibody

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Quick Overview

Mouse anti Human Neuregulin 1 k1G13

Product Description for Neuregulin 1

Mouse anti Human Neuregulin 1 k1G13.
Properties: (Beta-3)
Presentation: Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for Neuregulin 1

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms Acetylcholine receptor-inducing activity, Breast cancer cell differentiation factor p45, GGF, Glial growth factor, HGL, HRG, HRGA, Heregulin, NDF, NRG1, Neu differentiation factor, Pro-neuregulin-1 membrane-bound isoform, SMDF, Sensory and motor neuron-derived factor
Presentation Purified
Reactivity Hu
Applications E, WB
Clonality Monoclonal
Clone k1G13
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q02297
Immunogen:
Recombinant Human NRG1 isoform HRG-beta-3 (20-241aa) purified from E. coli.
GeneID:
3084
Property Beta-3
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. 
Recommended dilution range for Western blot analysis is 1/1,000~1/2,000.
Recommended starting dilution is 1/1,000.
Background Neuregulin1 (NRG1) is one of four proteins in the neuregulin family that act on the Epidermal growth factor receptor (EGFR) family of receptors. NRG1 was originally identified as a 44 kDa glycoprotein that interacts with the ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. In many brain areas, NRG1 is expressed at synaptic regions and its processing can be regulated by neuronal activity. This variant (HRG-beta3) of NRG1, along with HRG-alpha, beta1 and beta2 variants, was identified in various normal tissues and cancer cell lines.
Concentration 1.0 mg/ml
General Readings Talmage D.A, et al., (2008) Novartis Found Symp. 289:74-93. 
Li B, et al., (2007) Neuron. 54(4):583-597. 
Law A.J, et al., (2006) Proc Natl Acad Sci U S A. 103(17):6747-6752.
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity Chromatography on Protein G
Buffer System:
PBS, pH 7.4 containing 0.02% Sodium Azide and 10% Glycerol
State:
Liquid purified Ig fraction
Purified
Specificity
Specificity:
This Monoclonal k1G13 antibody recognizes Human NRG1 (HRG-beta-3). 
Other species not tested.

Accessory Products

Proteins and/or Positive Controls

Proteins for Neuregulin 1 (13 products)

Catalog No. Species Pres. Purity   Source  

Neuregulin 1 (transcript variant GGF2)

Neuregulin 1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €139.00
  OriGene Technologies, Inc.

Neuregulin 1 (beta-1 Isoform)

Neuregulin 1 Human Purified > 98 % > 98 % by SDS-PAGE gel and HPLC analyses E. coli
  OriGene Technologies GmbH

Neuregulin 1 (beta-1 Isoform)

Neuregulin 1 Human Purified > 98 % > 98 % by SDS-PAGE gel and HPLC analyses E. coli
  OriGene Technologies GmbH

Neuregulin 1

Neuregulin 1 Human Purified
  Abnova Taiwan Corp.

Neuregulin 1

Neuregulin 1 Human Purified
  Abnova Taiwan Corp.

Neuregulin 1

Neuregulin 1 Human
  Abnova Taiwan Corp.

Neuregulin 1

Neuregulin 1 Human
  Abnova Taiwan Corp.

Neuregulin 1

Neuregulin 1 Human
  Abnova Taiwan Corp.

Neuregulin 1

 Heregulin-B2 structure and sequence Human Purified > 95 % E. coli
10 µg / €310.00
  Neuromics Antibodies

Neuregulin 1

 Heregulin-B2 structure and sequence Human Purified > 95 % E. coli
50 µg / €440.00
  Neuromics Antibodies

Neuregulin 1

Functional Assay: Neuregulin 1 Protein [NBC1-21353] - The bioactivity was determined by dose-dependent cell proliferation assay for MCF-7 cells. ED50 for this NovActive™ NRG1 LOT lies in the range of 0.9-1.3 ng/ml. Affinity purified
  Novus Biologicals Inc.

Neuregulin 1

Neuregulin 1 Affinity purified
  Novus Biologicals Inc.

Neuregulin 1

Neuregulin 1 Affinity purified
  Novus Biologicals Inc.

Positive controls for Neuregulin 1 (4 products)

Catalog No. Species Pres. Purity   Source  

NRG1 293T Cell Transient Overexpression Lysate(Denatured)

NRG1 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

NRG1 293T Cell Transient Overexpression Lysate(Denatured)

NRG1 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

NRG1 Lysate

Western Blot: NRG1 Lysate [NBL1-13790] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for NRG1
  Novus Biologicals Inc.

NRG1 overexpression lysate

NRG1 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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