discontinued

AM50539PU-N Neuregulin-1 (Extracell. Dom) antibody

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0.1 mg / €440.00

Quick Overview

Mouse anti Mouse Neuregulin-1 D11

Product Description for Neuregulin-1

Mouse anti Mouse Neuregulin-1 D11.
Properties: (Extracell. Dom)
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Neuregulin-1

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms ERBB2 p185-activator), alpha (45kD, glial growth factor, heregulin, membrane-bound isoform, neu differentiation factor, neuregulin 1, pro-neuregulin-1, sensory and motor neuron derived factor
Presentation Purified
Reactivity Ms
Applications ICC/IF, WB
Clonality Monoclonal
Clone D11
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q6DR99
Immunogen:
His-tagged recombinant protein corresponding to mouse Neuregulin-1 at the extracellular domain.
GeneID:
211323
Property Extracell. Dom
Isotype control AM03095PU-N
Application Immunocytochemistry: A previous lot of this antibody was used successfully by an independent laboratory in IC. (Pirotte, D., et al.)
Western Blot: 0.25 µg/mL of this antibody detected Neuregulin-1 on 10 µg of mouse brain microsomal tissue lysate.
Background The group of Neuregulin-1 proteins are cell-cell signaling molecules and are ligands for receptor tyrosine kinases of the ErbB/HER subfamily. Type III NRG1 proteins (also referred to as CRD-NRG1 proteins) play a critical role in neural development, including myelination, motor and sensory neuron survival, and neuromuscular synapse development (Falls, 2003). Defects in animals lacking type III NRGs include retraction of nerve terminals from newly formed synapses, absence of Schwann cells from peripheral nerves, and loss of motor and sensory neurons (Wolpowitz et al., 2000). Available evidence indicates that most Type III NRG1 proteins are synthesized as transmembrane proteins with 2 TM domains, and that proteolytic processing produces a bioactive transmembrane form (NTFm) which serves as a juxtacrine signal (Wang, 2001; Falls, 2003).
Concentration lot-specific
Storage Store undiluted at 2-8°C.
Shelf life: one year from despatch.
Format
Purification:
Protein G Chromatography
Buffer System:
0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
State:
Liquid purified Ig fraction
Purified
Specificity
Specificity:
This antibody recognizes Neuregulin-1 at the extracellular domain.
Demonstrated to react with mouse.

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