AP13195PU-N Neuregulin 1 (Center) antibody

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0.4 ml / €370.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human Neuregulin 1

AP13195PU-N

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  • AP13195PU-N

Product Description for Neuregulin 1

Rabbit anti Human Neuregulin 1.
Properties: (Center)
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for Neuregulin 1

Product Category Primary Antibodies
Target Category
Quantity 0.4 ml
Synonyms Acetylcholine receptor-inducing activity, Breast cancer cell differentiation factor p45, GGF, Glial growth factor, HGL, HRG, HRGA, Heregulin, NDF, NRG1, Neu differentiation factor, Pro-neuregulin-1 membrane-bound isoform, SMDF, Sensory and motor neuron-derived factor
Presentation Purified
Reactivity Hu
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q02297
Immunogen:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human NRG1.
GeneID:
3084
Property Center
Application ELISA: 1/1,000.
Western Blot: 1/50 - 1/100.
Immunohistochemistry: 1/50 - 1/100.
Background Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
Caution This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration lot specific
General Readings
  1. Stove, C., et al., J. Invest. Dermatol. 121(4):802-812 (2003).
  2. Adelaide, J., et al., Genes Chromosomes Cancer 37(4):333-345 (2003).
  3. Ritch, P.A., et al., J. Biol. Chem. 278(23):20971-20978 (2003).
  4. Vermeer, P.D., et al., Nature 422(6929):322-326 (2003).
  5. Atlas, E., et al., Mol. Cancer Res. 1(3):165-175 (2003).
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Buffer System:
PBS with 0.09% (W/V) sodium azide
State:
Liquid purified Ig
Purified
Specificity
Specificity:
This antibody reacts to NRG1.
Species:
Human.
Gene ID 3084

Accessory Products

Proteins and/or Positive Controls

Proteins for Neuregulin 1 (13 products)

Catalog No. Species Pres. Purity   Source  

Neuregulin 1 (transcript variant GGF2)

Neuregulin 1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €139.00
  OriGene Technologies, Inc.

Neuregulin 1 (beta-1 Isoform)

Neuregulin 1 Human Purified > 98 % > 98 % by SDS-PAGE gel and HPLC analyses E. coli
  OriGene Technologies GmbH

Neuregulin 1 (beta-1 Isoform)

Neuregulin 1 Human Purified > 98 % > 98 % by SDS-PAGE gel and HPLC analyses E. coli
  OriGene Technologies GmbH

Neuregulin 1

Neuregulin 1 Human Purified
  Abnova Taiwan Corp.

Neuregulin 1

Neuregulin 1 Human Purified
  Abnova Taiwan Corp.

Neuregulin 1

Neuregulin 1 Human
  Abnova Taiwan Corp.

Neuregulin 1

Neuregulin 1 Human
  Abnova Taiwan Corp.

Neuregulin 1

Neuregulin 1 Human
  Abnova Taiwan Corp.

Neuregulin 1

 Heregulin-B2 structure and sequence Human Purified > 95 % E. coli
10 µg / €310.00
  Neuromics Antibodies

Neuregulin 1

 Heregulin-B2 structure and sequence Human Purified > 95 % E. coli
50 µg / €440.00
  Neuromics Antibodies

Neuregulin 1

Functional Assay: Neuregulin 1 Protein [NBC1-21353] - The bioactivity was determined by dose-dependent cell proliferation assay for MCF-7 cells. ED50 for this NovActive™ NRG1 LOT lies in the range of 0.9-1.3 ng/ml. Affinity purified
  Novus Biologicals Inc.

Neuregulin 1

Neuregulin 1 Affinity purified
  Novus Biologicals Inc.

Neuregulin 1

Neuregulin 1 Affinity purified
  Novus Biologicals Inc.

Positive controls for Neuregulin 1 (4 products)

Catalog No. Species Pres. Purity   Source  

NRG1 293T Cell Transient Overexpression Lysate(Denatured)

NRG1 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

NRG1 293T Cell Transient Overexpression Lysate(Denatured)

NRG1 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

NRG1 Lysate

Western Blot: NRG1 Lysate [NBL1-13790] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for NRG1
  Novus Biologicals Inc.

NRG1 overexpression lysate

NRG1 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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