TA324696 NEUROD1 (N-term) antibody

Rabbit polyclonal NeuroD1 Antibody (N-term)

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0.4 ml / €410.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human NEUROD1

TA324696

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Product Description for NEUROD1

Rabbit anti Human NEUROD1.
Properties: (N-term)
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for NEUROD1

Product Category Primary Antibodies
Target Category
Quantity 0.4 ml
Synonyms NEUROD, NEUROD1, Neurogenic differentiation factor 1
Presentation Purified
Reactivity Hu
Applications P
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q13562
Immunogen:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human NeuroD1.
GeneID:
4760
Property N-term
Add. information Molecular weight: 39890 Da
Application ELISA 1:1,000.
Immunohistochemistry 1:50 - 1:100.
Background NeuroD1 acts as a differentiation factor during neurogenesis. They are expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation. NeuroD1 is a basic helix-loop-helix (bHLH) protein contain 1 bHLH domain. NeuroD1 is a transcriptional activator, for efficient DNA binding it requires dimerization with another bHLH protein. It was reported that NeuroD1 involves heterodimerization with the ubiquitous bHLH protein E47, and regulates insulin gene expression by binding to a critical E-box motif on the insulin promoter. Defects in NEUROD1 causes maturity onset diabetes of the young type VI. MODY6 is a form of non-insulin-dependent diabetes mellitus (NIDDM) characterized by an autosomal dominant mode of inheritance, onset during young adulthood and a primary defect in insulin secretion.
Concentration 0.25 mg/ml
General Readings
  1. Breslin, M.B., et al., J. Biol. Chem. 278(40):38991-38997 (2003).
  2. Malecki, M.T., et al., Acta Diabetol 40(2):109-111 (2003).
  3. Cinek, O., et al., Diabetes Res. Clin. Pract. 60(1):49-56 (2003).
  4. Ye, L., et al., Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19(6):484-487 (2002).
  5. Kanatsuka, A., et al., Metab. Clin. Exp. 51(9):1161-1165 (2002).
Storage Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Buffer System:
PBS with 0.09% (W/V) sodium azide
State:
Liquid Ig fraction
Purified
Specificity
Specificity:
This antibody detects NeuroD1at N-term.
Species:
Human.

Accessory Products

Proteins and/or Positive Controls

Proteins for NEUROD1 (8 products)

Catalog No. Species Pres. Purity   Source  

NEUROD1

NEUROD1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €438.00
  OriGene Technologies, Inc.

NEUROD1

NEUROD1 Human
  Abnova Taiwan Corp.

NEUROD1

NEUROD1 Human Purified
  Abnova Taiwan Corp.

NEUROD1

NEUROD1 Human Purified
  Abnova Taiwan Corp.

NEUROD1

NEUROD1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

NEUROD1

NEUROD1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

NEUROD1

NEUROD1 Human
  Abnova Taiwan Corp.

NEUROD1

NEUROD1 Human
  Abnova Taiwan Corp.

Positive controls for NEUROD1 (3 products)

Catalog No. Species Pres. Purity   Source  

NEUROD1 293T Cell Transient Overexpression Lysate(Denatured)

NEUROD1 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

NeuroD1 Lysate

Western Blot: NeuroD1 Lysate [NBL1-13598] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for NEUROD1
  Novus Biologicals Inc.

NEUROD1 overexpression lysate

NEUROD1 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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