AP07467PU-N NFKBIA / IKBA antibody

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Search for all "NFKBIA / IKBA"

50 µl / €380.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse, Rat NFKBIA / IKBA

Product Description for NFKBIA / IKBA

Rabbit anti Human, Mouse, Rat NFKBIA / IKBA.
Presentation: Aff - Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot, Paraffin Sections.

Properties for NFKBIA / IKBA

Product Category Primary Antibodies
Target Category
Quantity 50 µl
Synonyms I kappa B-alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, MAD3, Major histocompatibility complex enhancer-binding protein MAD3, NF-kappa-B inhibitor alpha, NFKBI
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications IP, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P25963
Immunogen:
Synthetic peptide
GeneID:
4792
Application Immunohistochemistry on Paraffin Sections: 1/50.
Immunoprecipitation.
Western Blot.
Background Three major forms of IKB like molecules have been identified and each is characterised by multiple copies of ankyrin repeats. IKB alpha and IKB beta appear to be the major regulatory forms of IKB in most cells. These proteins interact with p65 or cRel containing forms of NFkB and block nuclear import by masking the nuclear localisation sequences of NFkB. The activation of NFkB involves the inducible phosphorylation and subsequent degradation of IKB. Immunoblotting easily detects the hyperphosphorylated forms of IKB alpha, but not phosphorylated IKB beta. Interestingly, IKB alpha and IKB beta mediate different NFkB responses. IkB alpha appears to control more transient activation of NFkB in response to an inducer, while IKB beta controls a persistent response. Bcl3 interacts with p50 and p52 containing forms of NFkB, but rather than being an inhibitor it appears to function to stimulate transcription. The degradation of IKB is confirmed by immunoblotting.
Storage Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.
Format
Purification:
Immunoaffinity Chromatography
Buffer System:
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% gelatin
State:
Liquid purified Ig
Aff - Purified
Specificity
Specificity:
This antibody reacts to a peptide mapping to the carboxy terminus of IkB-alpha.
Species:
Human, Mouse, Rat.
Gene ID 4792

Accessory Products

Proteins and/or Positive Controls

Proteins for NFKBIA / IKBA (5 products)

Catalog No. Species Pres. Purity   Source  

NFKBIA / IKBA

NFKBIA / IKBA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €438.00
  OriGene Technologies, Inc.

NFKBIA / IKBA (1-317, His-tag)

NFKBIA / IKBA Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €940.00
  OriGene Technologies GmbH

NFKBIA / IKBA (1-317, His-tag)

NFKBIA / IKBA Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €370.00
  OriGene Technologies GmbH

NFKBIA / IKBA

NFKBIA / IKBA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

NFKBIA / IKBA

NFKBIA / IKBA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.
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