discontinued

TA336424 NFKBIA / IKBA antibody

Mouse Monoclonal IkB-alpha Antibody (5D1623)

See related secondary antibodies

Search for all "NFKBIA / IKBA"

Quick Overview

Mouse anti Human NFKBIA / IKBA 5D1623

Product Description for NFKBIA / IKBA

Mouse anti Human NFKBIA / IKBA 5D1623.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for NFKBIA / IKBA

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms I kappa B-alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, MAD3, Major histocompatibility complex enhancer-binding protein MAD3, NF-kappa-B inhibitor alpha, NFKBI
Presentation Purified
Reactivity Hu
Applications WB
Clonality Monoclonal
Clone 5D1623
Host Mouse
Isotype IgG1
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P25963
Immunogen:
This monoclonal antibody was developed against a synthetic peptide corresponding to the caspase-3 mediated cleavage site of IkBa.
GeneID:
4792
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application WB: 1 ug/ml
Background NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kise complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. Exterl stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. Recent studies have shown that IkBa can be cleaved by caspases during apoptosis to produce an amino-termil truncated IkBa (DN-IkBa). The DN-IkBa is resistant to degradation in response to inducers of NF-kB and act as domint inhibitory molecule that suppresses NF-kB activity during apoptosis.
Format
Purification:
Protein G purified
Buffer System:
PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Proteins for NFKBIA / IKBA (5 products)

Catalog No. Species Pres. Purity   Source  

NFKBIA / IKBA

NFKBIA / IKBA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €438.00
  OriGene Technologies, Inc.

NFKBIA / IKBA (1-317, His-tag)

NFKBIA / IKBA Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €940.00
  OriGene Technologies GmbH

NFKBIA / IKBA (1-317, His-tag)

NFKBIA / IKBA Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €370.00
  OriGene Technologies GmbH

NFKBIA / IKBA

NFKBIA / IKBA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

NFKBIA / IKBA

NFKBIA / IKBA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.
  • LinkedIn