NB100-74479 nNOS [Ser1417] Phosphospecific antibody

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0.1 mg / €360.00

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Rabbit anti Rat nNOS [Ser1417] Phosphospecific


Product Description for nNOS [Ser1417] Phosphospecific

Rabbit anti Rat nNOS [Ser1417] Phosphospecific.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for nNOS [Ser1417] Phosphospecific

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms neuronal
Presentation Aff - Purified
Reactivity Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic phosphopeptide corresponding to residues C N(a.a. 1411) R L R S E (pS) I A F I E E S K(a.a. 1425) of human nNOS.
Application Western Blot 2 ug/ml
Background Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains.

iNOS is found in a variety of cell types including macrophages, hepatocytes, synoviocytes, and smooth muscle cells. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. After cytokine induction, iNOS exhibits a delayed activity response which is then followed by a significant increase in NO production over a long period of time.
Storage Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Immunogen affinity purified
Immunogen affinity purified
Aff - Purified
This antibody is reactive against Rat.

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