SM5046P Nonspecific Cytotoxic Cells antibody

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Mouse anti Bovine, Canine, Equine, Fish, Porcine, Rat Nonspecific Cytotoxic Cells 5C.6


Product Description for Nonspecific Cytotoxic Cells

Mouse anti Bovine, Canine, Equine, Fish, Porcine, Rat Nonspecific Cytotoxic Cells 5C.6.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Immunoprecipitation, Western blot / Immunoblot, Flow Cytometry.

Properties for Nonspecific Cytotoxic Cells

Product Category Primary Antibodies
Quantity 0.2 mg
Presentation Purified
Reactivity Bov, Can, Eq, Fi, Por, Rt
Applications E, F, IP, WB
Clonality Monoclonal
Clone 5C.6
Host Mouse
Isotype IgM
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Purified NCC cells from catfish.
Isotype control SM13P
Application Western Blot: 10 µg/ml, detects a 32 kDa protein representing nonspecific cytotoxic cell receptor protein.
Flow Cytometry.
Background Non-specific cytotoxic cells (NCCs) in teleosts and their evolutionary homologue are a subpopulation of lymphocytes with properties that distinguish them from either B- or T-cells. One such property is that NCC/natural killer (NK)/lymphokine activated killer (LAK) cells express spontaneous, non-major histocompatibility complex restricted cytotoxic activity. NCC and LAK lyse a variety of transformed murine and human B-cell, T-cell and myeloid targets. A 32 kDa membrane protein [non-specific cytotoxic cell receptor protein (NCCRP-1)] expressed by NCC and certain mammalian NK/LAK cells mediates this cytotoxicity. NCCRP-1 is evolutionarily conserved and is found in species ranging from marine and freshwater teleosts to higher mammals.
Concentration 0.73 mg/ml
General Readings
  1. Mol. Immunol. 34:955-965, 1997.
  2. Cell. Immunol. 187:19-26, 1998.
  3. Natural Immunity 16:18-26, 1998.
  4. Dev. Comp. Immunol. 23:521-532, 1999.
Storage Aliquot and store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
PBS with 0.05% sodium azide as preservative and 1 mg/ml BSA as stabilizer
Liquid purified Ig fraction.
This antibody detects nonspecific cytotoxic cells (NCC) and tilapia tissue and also detects natural killer/lymphokine activated killer (KN/LAK) cells.
Bovine, Canine, Equine, Fish, Porcine, Rat.

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