discontinued

NB120-3868 NOS antibody

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0.1 mg / €420.00

Quick Overview

Rabbit anti NOS

NB120-3868

Product Description for NOS

Rabbit anti NOS.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Immunoprecipitation, Western blot / Immunoblot.

Properties for NOS

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Applications E, IP, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide surrounding Serine 116 of bovine eNOS.
Background Endogenous Nitric Oxide (NO) is a diffusible multifunctional second messenger that has been implicated in numerous physiological functions in mammals, such as blood vessel dilation, immune response and synaptic transmission enhancement. The NO is derived from L-arginine as the product of a complex enzymatic reaction catalyzed by a family of three NO synthase (NOS) proteins: nNOS (typeI),iNOS (Type II), eNOS (type III).The endothelial NOS (eNOS) plays a critical role in controlling vascular tone, platelet aggregation, and cardiac myocyte function. It is strongly expressed in malignant mesothelioma, but is not associated with expression of vascular endothelial growth factor (VEGF) and its receptors. This phenomenon is different from what has been shown in non-neoplastic endothelial cells.
General Readings General / background references:Soini Y et al. Endothelial nitric oxide synthase is strongly expressed in malignant mesothelioma but does not associate with vascular density or the expression of VEGF, FLK1 or FLT1. Histopathology 39:179-86 (2001). PubMed PMID: 11493335
Loscalzo J & Welch G Nitric oxide and its role in the cardiovascular system. Prog Cardiovasc Dis 38:87-104 (1995). PubMed PMID: 7568906
Bredt DS & Snyder SH Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 63:175-95 (1994). PubMed PMID: 7526779
Nathan C & Xie QW Regulation of biosynthesis of nitric oxide. J Biol Chem 269:13725-8 (1994). PubMed PMID: 7514592
Format
Purification:
Immunogen affinity purified
Buffer System:
PBS with 0.02% sodium azide
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Species:
Cross-reacts with Cow.Not yet tested in other species.

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