discontinued

GTX28928 Notch1 intra + Notch2 intra antibody

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0.2 ml / €440.00

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Rabbit anti Human, Rat Notch1 intra + Notch2 intra

GTX28928

Product Description for Notch1 intra + Notch2 intra

Rabbit anti Human, Rat Notch1 intra + Notch2 intra.
Presentation: Serum
Product is tested for Enzyme Immunoassay.

Properties for Notch1 intra + Notch2 intra

Product Category Primary Antibodies
Quantity 0.2 ml
Synonyms NOTCH-1, Neurogenic locus notch homolog Protein 1, Notch1, TAN-1, TAN1, Translocation-associated Notch Protein TAN-1, hN1
Presentation Serum
Reactivity Hu, Rt
Applications E
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Peptide: CEHPFLTPSPESPDQ from Notch 1 (aa2507-2520) - lying 35 amino acids from the C-terminus.The sequence in Notch 2 differs by 1 amino acid.
Application ELISA
Background Synthesized in the endoplasmic reticulum as an inactive form, which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
Storage Keep as concentrated solution. Store at 4
Format
Purification:
Whole antiserum
Buffer System:
serum with 0.02% sodium azide
Purity:
Whole antiserum
State:
Liquid
Serum
Specificity
Specificity:
Does not cross-react with Mouse. Expected to cross-react with Human (100% identity with immunogen), Rat (100% identity with immunogen) due to sequence homology. Not yet tested in other species.

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