discontinued

NB120-8928 Notch1 intra + Notch2 intra antibody

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0.2 ml / €260.00

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Rabbit anti Notch1 intra + Notch2 intra

NB120-8928

Product Description for Notch1 intra + Notch2 intra

Rabbit anti Notch1 intra + Notch2 intra.
Presentation: Serum

Properties for Notch1 intra + Notch2 intra

Product Category Primary Antibodies
Quantity 0.2 ml
Synonyms NOTCH-1, Neurogenic locus notch homolog Protein 1, Notch1, TAN-1, TAN1, Translocation-associated Notch Protein TAN-1, hN1
Presentation Serum
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Peptide: CEHPFLTPSPESPDQ from Notch 1 (aa2507-2520) - lying 35 amino acids from the C-terminus.The sequence in Notch 2 differs by 1 amino acid.
Background Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membraneFunctions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
Format
Purification:
Whole antisera
Buffer System:
serum with 0.02% sodium azide
Purity:
Whole antisera
State:
Serum
Specificity
Species:
Does not cross-react with Mouse.Expected to cross-react with Human (100% identity with immunogen), Rat (100% identity with immunogen) due to sequence homology.Not yet tested in other species.

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