TA500078 NOTCH1 antibody

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0.1 ml / €379.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Mouse anti Human NOTCH1 OTI3E12

TA500078

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Product Description for NOTCH1

Mouse anti Human NOTCH1 OTI3E12.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections, Western blot / Immunoblot.

Properties for NOTCH1

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms Neurogenic locus notch homolog protein 1, Notch 1, TAN1, hN1
Presentation Purified
Reactivity Hu
Applications ICC/IF, P, WB
Clonality Monoclonal
Clone OTI3E12
Host Mouse
Isotype IgG2b
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P46531
Immunogen:
Recombinant protein expressed in E.coli corresponding to amino acids 2300-2556 of human NOTCH1.
GeneID:
4851
Isotype control AM03110PU-N, SM12P
Application WB: 1:1000; IHC 1;50; RPPA 1:75; IF: 1:100
Background Notch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch sigling network is an evolutiorily conserved intercellular sigling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular sigling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development
Product Citations
Originator or purchased from resellers:
  1. Harada K, Sato Y, Ikeda H, Hsu M, Igarashi S, Nakanuma Y. Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours. J Clin Pathol. 2013 May;66(5):386-91. doi: 10.1136/jclinpath-2012-201273. Epub 2013 Feb 19. PubMed PMID: 23423517.
Format
Purification:
Puridied form mouse ascites fluids
Buffer System:
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Proteins for NOTCH1 (4 products)

Catalog No. Species Pres. Purity   Source  

NOTCH1

NOTCH1 n/a
50 µg / €260.00
  GeneTex Inc.

NOTCH1

NOTCH1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

NOTCH1

NOTCH1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

NOTCH1 / NOTCH2 (Intra)

NOTCH1 / NOTCH2 n/a
50 µg / €240.00
  GeneTex Inc.

Positive controls for NOTCH1 (1 products)

Catalog No. Species Pres. Purity   Source  

Notch1 Lysate

Western Blot: Notch1 Lysate [NBL1-13725] - Western Blot experiments.  Left-Control; Right -Over-expression Lysate for NOTCH1.
0.1 mg / €620.00
  Novus Biologicals Inc.
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