discontinued

NBP1-00956 Npy2r antibody

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0.1 mg / €390.00

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Rabbit anti Human, Mouse, Rat Npy2r

NBP1-00956

Product Description for Npy2r

Rabbit anti Human, Mouse, Rat Npy2r.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Western blot / Immunoblot.

Properties for Npy2r

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Neuropeptide Y receptor Y2
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications ICC/IF, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q8BWV1
GeneID:
18167
Application ELISA, Western Blot, Western blot analysis of NPY2-R (D42) antibody in extracts from HepG2 cells. Detects a band at molecular weight: 48kDa, ELISA 1:1000-1:5000, Western Blot 1:500-1:1000,
Background A gene on chromosome 4q31 encodes a 381 amino acid protein, NPY2-R(also designated Neuropeptide Y receptor Y2). NPY2-R is a member of the Gprotein-coupled receptor super-family, and like other members has seven putative transmembrane domains. However, NPY2-R gene consists of two exons, unlike the contiguous structure of other G-protein-coupled receptor genes. NPY2-R shares a 31% sequence identity with NPY1-R. NPY2-R is expressed in the presynaptic membranes of the central nervous system, and to a lesser extent the peripheral nervous system. NPY2-R associates (from highest to lowest affinity) with carboxyl terminals of unphosphorylate Peptide YY (PYY) (phosphorylation of PYY greatly reduces its binding affinity), NPY, and Pancreatic Peptide. Depending on the cell type, NPY2-R couples with different G proteins, which act as different second messengers. NPY2-R reduces the effects of depolarization, calcium ion currents in arterial smooth muscle by through association with NPY. NPY2-R inhibits cholecystokinin octapeptide-induced, esophageal muscle contraction, through interactions with PYY and NPY.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
Immunogen affinity purified
Buffer System:
15mM Sodium Azide
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Specificity:
NPY2-R (D42) detects endogenous levels of NPY2-R protein.
Species:
Human, Mouse, Rat
Gene ID 18167

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