AM08256SU-N Nuclear Pore Complex Marker (pan) antibody

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Mouse anti Human, Mouse, Rat, Yeast Nuclear Pore Complex Marker 39C7

Product Description for Nuclear Pore Complex Marker

Mouse anti Human, Mouse, Rat, Yeast Nuclear Pore Complex Marker 39C7.
Properties: (pan)
Presentation: Supernatant
Product is tested for Immunocytochemistry/Immunofluorescence.

Properties for Nuclear Pore Complex Marker

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms NPC, NUP107, NUP84, Nuclear Pore Complex Proteins, Nuclear stain of multiple gene products including Nup62, Nup133, Nup62
Presentation Supernatant
Reactivity Hu, Ms, Rt, Ye
Applications ICC/IF
Clonality Monoclonal
Clone 39C7
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Yeast nuclear preparations.
Property pan
Application Immunofluorescence: 1/50-1/100.
Background The Nuclear Pore Complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993; Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001).
General Readings
  1. Nakielny S, Dreyfuss G. Transport of proteins and RNAs in and out of the nucleus. Cell. 1999 Dec 23;99(7):677-90. PubMed PMID: 10619422.
  2. Wilken N, Kossner U, Senécal JL, Scheer U, Dabauvalle MC. Nup180, a novel nuclear pore complex protein localizing to the cytoplasmic ring and associated fibrils. J Cell Biol. 1993 Dec;123(6 Pt 1):1345-54. PubMed PMID: 8253835. (Free PMC Article available)
  3. Nesher G, Margalit R, Ashkenazi YJ. Anti-nuclear envelope antibodies: Clinical associations. Semin Arthritis Rheum. 2001 Apr;30(5):313-20. PubMed PMID: 11303304.
  4. Jaju RJ, Fidler C, Haas OA, Strickson AJ, Watkins F, Clark K, et al. A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. Blood. 2001 Aug 15;98(4):1264-7. PubMed PMID: 11493482.
Storage Store the antibody undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
10 mM Sodium Azide
Concentrated Culture Supernatant
Species Reactivity
Species reactivity (tested):
Human, Mouse, Rat and Yeast.
This antibody reacts with a Nuclear Pore Complex protein.
Clone 39C7 was one of a series of clones which strongly and specifically labelled the nuclear pore complex.

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