bs-11958R OTX1 + OTX2 antibody

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Rabbit anti Human, Mouse, Rat OTX1 + OTX2


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  • bs-11958R

Product Description for OTX1 + OTX2

Rabbit anti Human, Mouse, Rat OTX1 + OTX2.
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for OTX1 + OTX2

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms Homeobox protein OTX-1, Homeobox protein OTX-2, Orthodenticle homolog 1, Orthodenticle homolog 2
Presentation Purified
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer Bioss, Inc.

Datasheet Extract

KLH conjugated synthetic peptide derived from human OTX1 + OTX2.
Background Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, respectively.
Storage Store at -20°C for 12 months.
Purified by Protein A and peptide affinity chromatography.
Buffer System:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.

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