BM6042P Ovarian Carcinoma-associated antigen antibody

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Mouse anti Human Ovarian Carcinoma-associated antigen OVTL-16


Product Description for Ovarian Carcinoma-associated antigen

Mouse anti Human Ovarian Carcinoma-associated antigen OVTL-16.
Presentation: Supernatant
Product is tested for Frozen Sections, Immunocytochemistry/Immunofluorescence.

Properties for Ovarian Carcinoma-associated antigen

Product Category Primary Antibodies
Quantity 1 ml
Presentation Supernatant
Reactivity Hu
Applications C, ICC/IF
Clonality Monoclonal
Clone OVTL-16
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunized with cyst fluid, obtained from a patient with a poorly differentiated human ovarian carcinoma.
Application Immunohistochemistry on Frozen Tissues and for staining with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent.
Background A central concept in tumor immunology is that malignancies bear tumor associated antigens, which are not or to a much lesser degree found in normal tissues. These antigens can be used as distinctive markers in diagnosis and therapy. As a consequence, monoclonal antibodies to such antigens may represent useful tools for histopathology, immunoscintigraphy and for immunotherapy.
General Readings
  1. Boerman O, Makkink K, Massuger L, Thomas C, Kenemans P, Hanselaar T, et al. Monoclonal antibodies against ovarian carcinoma-associated antigens, raised by immunization with cyst fluids. Anticancer Res. 1989 May-Jun;9(3):551-8. PubMed PMID: 2764501.
  2. Boerman O, Massuger L, Makkink K, Thomas C, Kenemans P, Poels L. Comparative in vitro binding characteristics and biodistribution in tumor-bearing athymic mice of anti-ovarian carcinoma monoclonal antibodies. Anticancer Res. 1990 Sep-Oct;10(5A):1289-95. PubMed PMID: 2241105.
  3. Van Niekerk CC, Ramaekers FC, Hanselaar AG, Aldeweireldt J, Poels LG. Changes in expression of differentiation markers between normal ovarian cells and derived tumors. Am J Pathol. 1993 Jan;142(1):157-77. PubMed PMID: 7678716. (Free PMC Article available)
  4. Slobbe R, Poels L, ten Dam G, Boerman O, Nieland L, Leunissen J, et al. Analysis of idiotope structure of ovarian cancer antibodies: recognition of the same epitope by two monoclonal antibodies differing mainly in their heavy chain variable sequences. Clin Exp Immunol. 1994 Oct;98(1):95-103. PubMed PMID: 7523009. (Free PMC Article available)
  5. van Niekerk CC, Vooijs P, Casparie-van Velsen IJ, Poels LG. Differentiation margins of ovarian tumor pathology: first incidences of epithelial ovarian tumors monitored by marker antibodies. Cancer Detect Prev. 1997;21(3):247-57. PubMed PMID: 9167042.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freeze-thaw cycles.
Shelf life: One year from despatch.
0.09% Sodium Azide
Liquid Culture Supernatant
OVTL16 recognizes a conformational epitope on ovarian carcinoma membrane antigen OA3 which is present in ovarian carcinomas and in cyst fluids obtained from these carcinomas, as well as in oviductal carcinomas and some endometrial carcinomas.

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