discontinued

GTX30659 p19ARF [12-A1-1] antibody

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0.1 ml / €410.00

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anti Mouse p19ARF [12-A1-1] 12-A1-1

GTX30659

Product Description for p19ARF [12-A1-1]

anti Mouse p19ARF [12-A1-1] 12-A1-1.
Product is tested for Western blot / Immunoblot.

Properties for p19ARF [12-A1-1]

Product Category Primary Antibodies
Quantity 0.1 ml
Reactivity Ms
Applications WB
Clonality Monoclonal
Clone 12-A1-1
Isotype IgG2b
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
A synthetic peptide containing amino acids 54-75 of the murine p19ARF.
Application WB
Background In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals.Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression.
Concentration 4.6 mg/ml
Storage Store at 4 degrees Celcius. For long-term storage, aliquot and store at -20 degrees Celcius. Avoid repeated freeze-thaws.
Format
State:
0.1 ml of raw ascites. Contains 0.1% sodium azide.
Specificity
Specificity:
This antibody reacts with mouse protein. It does not react with human or Golden hamster. Armenian hamster has not been tested.

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