discontinued

GTX22830 p300 antibody

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0.1 mg / €440.00

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Rabbit anti Human p300

GTX22830

Product Description for p300

Rabbit anti Human p300.
Presentation: Ig Fraction
Product is tested for Western blot / Immunoblot.

Properties for p300

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Ig Fraction
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide: GTSGPNQGPTQSTC , corresponding to amino acids 139-151 in the nuclear factor binding domain of Human p300.
Application WB
Background Cyclic AMP-responsive enhancer binding protein (CREB) binding protein (CBP) and p300 are closely related transcriptional coactivators and have been shown to directly interact with many different DNA-binding transcription factors including nuclear hormone receptors, CREB, c-Fos, c-Jun/v-Jun, c-Myb/v-Myb, TFIIB and MyoD. Both CBP and p300 have been shown to display histone acetyltransferase (HAT) activity, capable of acetylating all four core histone particles in nucleosomes. As a result of HAT activity, it has been suggested CBP and p300 may play a direct role in activating chromatin for transcription. Single point mutations in CBP have been proposed as causative factors in the developmental abnormalities of Rubinstein-Taybi syndrome (RTS). Although both CBP and p300 appear to function similarly, the inability of p300 to rescue CBP malfunction in RTS suggests intrinsic functional differences between CBP and p300.
Concentration 1 mg/ml
Storage Upon receipt - Keep as concentrated solution. Aliquot and store at -20
Format
Purification:
IgG fraction
Buffer System:
PBS, 1 mg/ml BSA, 0.05% sodium azide
Purity:
IgG fraction
State:
Liquid
Ig Fraction
Specificity
Specificity:
Human - Not yet tested in other species

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