discontinued

GTX23222 p35 Nck5a [ES19] antibody

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0.5 ml / €380.00

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Mouse anti Human p35 Nck5a [ES19] ES19

GTX23222

Product Description for p35 Nck5a [ES19]

Mouse anti Human p35 Nck5a [ES19] ES19.
Presentation: Purified
Product is tested for Immunoprecipitation.

Properties for p35 Nck5a [ES19]

Product Category Primary Antibodies
Quantity 0.5 ml
Presentation Purified
Reactivity Hu
Applications IP
Clonality Monoclonal
Clone ES19
Host Mouse
Isotype IgG2b
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Recombinant full length protein (Human).
Isotype control AM03110PU-N, SM12P
Application IP
Background p35 / nck5a, is a neuron-specific activator of Cdk 5. Treatment of cultured neurons with cyclohexamide induces the rapid disappearance of p35 accompanied by parallel inactivation of the kinase activity of Cdk 5. The disappearance of p35 is blocked with proteasome inhibitors, indicating the involvement of proteasome. The degradation of p35 is induced with okadaic acid in the presence of ATP in neuron extracts. The degradation of p35 by proteasome in cultured neurons is stimulated by okadaic acid in the absence of cyclohexamide. Cdk 5 and its neuron specific regulator p35 are essential for neuronal migration and for the laminar configuration of the cerebral cortex. p35 / Cdk 5 kinase concentrates at the leading edges of axonal growth cones and regulates neurite outgrowth in cortical neurons in culture. p35 / Cdk 5 kinase co-localizes with Rac in neuronal growth cones.
Concentration 0.2 mg/ml
Storage Keep as concentrated solution, aliquot and store at 4
Format
Purification:
Protein A purified
Buffer System:
10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Purity:
Protein A purified
State:
Liquid
Purified
Specificity
Specificity:
Human - Not yet tested in other species

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