NBP1-22839 p53 (TP53) antibody

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6 ml / €360.00

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Rabbit anti Human p53 (TP53) SP5


Product Description for p53 (TP53)

Rabbit anti Human p53 (TP53) SP5.
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for p53 (TP53)

Product Category Primary Antibodies
Quantity 6 ml
Synonyms Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53
Presentation Purified
Reactivity Hu
Applications P
Clonality Monoclonal
Clone SP5
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Recombinant human full-length wild type p53 protein.
Add. information Intended Use: This product is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, to be viewed by light microscopy. Clinical interpretation of staining results should be accompanied by histological studies with proper controls. Patients
Research Areas: Stem Cell Markers
Application immunohistochemistry, Immunohistochemistry-Paraffin, This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded and acetone fixed cryostat tissue sections. No further titration is required., immunohistochemistry , Immunohistochemistry-Paraffin
Background p53 plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNAPK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage. Chk2 and Chk1 can phosphorylate p53 at Ser20, enhancing its tetramerization, stability and activity. p53 is phosphorylated at Ser392 in vivo and by CAK in vitro. Phosphorylation of p53 at Ser392 is altered in human tumors and has been reported to influence the growth suppressor function, DNA binding and transcriptional activation of p53. p53 is phosphorylated at Ser6 and Ser9 by ck1d and ck1e both in vitro and in vivo. Phosphorylation of p53 at Ser46 is important in regulating the ability of p53 to induce apoptosis. In vivo phosphorylation of p53 at Ser33 by cdk7/cyclin H and in response to UV irradiation has been observed.
Storage Store at 4C. Do not freeze.
IgG purified
Buffer System:
No Preservative
IgG purified
This recognizes the p53 protein a tumor suppressor gene expressed in a wide variety of tissue types that is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen, and human papilloma virus E6 protein. p53 senses ????

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