AP01848PU-N p70 S6 Kinase (p70S6K) pThr229 antibody

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Rabbit anti Human, Mouse, Rat p70 S6 Kinase (p70S6K)


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  • AP01848PU-N

Product Description for p70 S6 Kinase (p70S6K)

Rabbit anti Human, Mouse, Rat p70 S6 Kinase (p70S6K).
Properties: pThr229
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot, Paraffin Sections.

Properties for p70 S6 Kinase (p70S6K)

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms K6B1, P70 beta 1, RPS6KB1, RPS6KB2, Ribosomal protein S6 kinase 70kDa polypeptide 2, STK14A, Serine/threonine kinase 14 alpha, p70 ribosomal S6 kinase beta 1, p70S6K, p70S6Kb Ribosomal protein S6 kinase 70kDa polypeptide 1
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Molecular weight ~59,70,85 kDa
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Property pThr229
Application Western blot: 1/500-1/1000.
Immunohistochemistry on paraffin sections: 1/50-1/200.
Background In studies to elucidate key regulatory pathways in signal transduction, several protein Serine/Threonine (Ser/Thr) kinases have been identified, including two distinct families of 40S ribosomal protein S6 Ser/Thr kinases present in somatic animal cells, designated p70 S6 kinase and p90 Rsk kinase. p90 Rsk kinase is maximally activated within minutes of addition of growth factors or phorbol ester to cultured cells followed by activation of p70 S6 kinase. Both enzymes are regulated by Serine/Threonine phosphorylation, suggesting that specific kinases may exist upstream in the signaling pathway that regulate these kinases. In fact, evidence suggests that one such family of activating enzymes includes the members of the ERK MAP kinase family. The ERK MAP kinases are, in turn, regulated by phosphorylation at Threonine and Tyrosine residues by a protein kinase designated MEK.
Concentration 1.0 mg/ml
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Affinity Chromatography using epitope-specific immunogen.
Buffer System:
Phosphate buffered saline (PBS), pH~7.2
0.09% sodium azide
50% glycerol
Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Aff - Purified
Species Reactivity
Species reactivity (expected):
Mouse and Rat.
Species reactivity (tested):
This antibody detects endogenous levels of p70 S6K pThr229 protein.

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