NB100-263 p95/nibrin/NBS1 pSer343 antibody

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Rabbit anti Mouse p95/nibrin/NBS1 pSer343


Product Description for p95/nibrin/NBS1 pSer343

Rabbit anti Mouse p95/nibrin/NBS1 pSer343.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for p95/nibrin/NBS1 pSer343

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Aff - Purified
Reactivity Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

A synthetic peptide made to mouse NBS1, phosphorylated at Ser343.
Application Western Blot
Background The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
General Readings
  1. Williams, B.R., et al. A murine model of Nijmegen breakage syndrome. Curr. Biol. 12(8): 658-653, 2002. (Mouse)
  2. Falck J, Petrini JH, Williams BR, Lukas J, Bartek J. The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet. 2002 Mar;30(3):290-4. Epub 2002 Feb 19. PubMed PMID: 11850621.
Storage Store at 4C. Do not freeze.
peptide affinity purified
peptide affinity purified
Aff - Purified
This antibody is specific for mouse NBS1 phosphorylated at Ser343. Not suitable for human samples.

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