GTX14459 PADPR [10H] antibody

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0.1 mg / €340.00

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Mouse anti Bovine PADPR [10H] 10H

Product Description for PADPR [10H]

Mouse anti Bovine PADPR [10H] 10H.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, Western blot / Immunoblot.

Properties for PADPR [10H]

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Bov
Applications C, E, WB
Clonality Monoclonal
Clone 10H
Host Mouse
Isotype IgG3
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

PADPR mixed with methylated bovine serum albumin.
Isotype control AM03097PU-N
Application ELISA, IHC-Fr, WB
Background PADPR (Poly(ADP-ribose)) is a polymer synthesized by a class of enzymes named poly(ADP-ribose) polymerases (PARP). Using NAD+ as substrate, PARP catalyzes the formation of the polymer PADPR, with chain lengths ranging from 2 to 300 residues, containing approximately 2% branching in the chain. PADPR becomes attached to nuclear proteins, and to PARP itself (automodification). Under normal conditions, cells display low basal level of PADPR polymer, which can dramatically increase in cells exposed to DNA damaging agents (irradiation, alkylation, etc.). This increase of polymer synthesis is usually transient and is followed by a rapid degradation phase with a short half life which can be less than 1 min. The low endogenous level of polymer in unstimulated cells and its rapid catabolism during DNA damage has been ascribed to high activity of the polymer catabolizing enzyme poly(ADP-ribose) glycohydrolyase (PARG).
Concentration 1 mg/ml
Protein A purified
Buffer System:
Preservative: 0.02% Sodium Azide; Constituents: 1% BSA, 20mM Tris, 150mM Sodium Chloride. pH 7.4
Protein A purified
Expected to cross-react with a wide range of species due to sequence homology.

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