discontinued

NB120-5247 PAK 1 + 2 + 3 antibody

See related secondary antibodies

Search for all "PAK 1 + 2 + 3"

0.05 ml / €380.00

Quick Overview

Rabbit anti Human PAK 1 + 2 + 3

NB120-5247

Product Description for PAK 1 + 2 + 3

Rabbit anti Human PAK 1 + 2 + 3.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for PAK 1 + 2 + 3

Product Category Primary Antibodies
Quantity 0.05 ml
Synonyms CDKN1A
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Chemically synthesized phosphopeptide derived from a region of human PAK2 that contains serine 141. The sequence is conserved in rat and rabbit.
Background P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
General Readings General / background references:Kissil JL et al. Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J Biol Chem 277:10394-9 (2002). PubMed PMID: 11782491
Roig J et al. Cdc42-independent activation and translocation of the cytostatic p21-activated protein kinase gamma-PAK by sphingosine. FEBS Lett 507:195-9 (2001). PubMed PMID: 11684097
Dechert MA et al. p21-activated kinase 1 participates in tracheal smooth muscle cell migration by signaling to p38 Mapk. Am J Physiol Cell Physiol 281:C123-32 (2001). PubMed PMID: 11401834
Chong C et al. The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J Biol Chem 276:17347-53 (2001). PubMed PMID: 11278486
Format
Purification:
Immunogen affinity purified
Buffer System:
Preservative: 0.05% Sodium AzideConstituents: PBS, 1mg/ml BSA (IgG, protease free). pH 7.3
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Species:
Cross-reacts with Human.Expected to cross-react with Rabbit and Rat due to sequence homology.Not yet tested in other species.

Accessory Products

  • LinkedIn