NSB940 PAK 1 + 2 + 3 antibody

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Rabbit anti Human PAK 1 + 2 + 3

Product Description for PAK 1 + 2 + 3

Rabbit anti Human PAK 1 + 2 + 3.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for PAK 1 + 2 + 3

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Chemically synthesized phosphopeptide derived from a region of human PAK2 that contains serine 141. The sequence is conserved in rat and rabbit.
Add. information Research Areas: Cancer
Application Western Blot, Western Blot Predicted molecular weight 65 kDa. , Western Blot 0.1 - 1.0 ug/ml
Background P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
Concentration 0.5 mg/ml
General Readings General / background references:Kissil JL et al. Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J Biol Chem 277:10394-9 (2002). PubMed PMID: 11782491
Roig J et al. Cdc42-independent activation and translocation of the cytostatic p21-activated protein kinase gamma-PAK by sphingosine. FEBS Lett 507:195-9 (2001). PubMed PMID: 11684097
Dechert MA et al. p21-activated kinase 1 participates in tracheal smooth muscle cell migration by signaling to p38 Mapk. Am J Physiol Cell Physiol 281:C123-32 (2001). PubMed PMID: 11401834
Chong C et al. The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J Biol Chem 276:17347-53 (2001). PubMed PMID: 11278486
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
0.05% Sodium Azide
Immunogen affinity purified
Aff - Purified
PAK 1 + 2 + 3 Phosphospecific [Ser141]

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