NB110-59928 Pan Melanoma antibody

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Mouse anti Human Pan Melanoma HMB45+M2-7C10+M2-9E3+T311


Product Description for Pan Melanoma

Mouse anti Human Pan Melanoma HMB45+M2-7C10+M2-9E3+T311.
Product is tested for Frozen Sections.

Properties for Pan Melanoma

Product Category Primary Antibodies
Quantity 6 ml
Reactivity Hu
Applications C
Clonality Monoclonal
Clone HMB45+M2-7C10+M2-9E3+T311
Host Mouse
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Pigmented melanoma metastases from lymph nodes (HMB45). Recombinant human MART-1 protein (MART1). Recombinant tyrosinase protein (Tyrosinase).
Background Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre existing benign nevus, which occurs most often in the skin but also may involve other sites.
The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells and is thought to be oncofetal in nature. This antibody has been shown to label the majority of melanomas. The MART-1/Melan A recognizes a protein of 18kDa, identified at MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown Tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has also shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45 and the MART-1 (cocktail) and Tyrosinase make this quadruple antibody cocktail a first-order pan melanoma screener.
General Readings Chen et al. Proc Natl Acad Sci USA 92: 8125, 1995.
Gown et al. Am J Pathol 123: 195, 1986.
Kapur et al. J Histochem Cytochem 40: 207, 1992.
Buffer System:
Tissue culture supernatant
This antibody is reactive against human.

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