NB110-7203 Parkin antibody

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Rabbit anti Human, Rat Parkin


Product Description for Parkin

Rabbit anti Human, Rat Parkin.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for Parkin

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms E3 ubiquitin-protein ligase Parkin, EC=6.3.2.-, PARK2, PRKN, Parkinson disease protein 2
Presentation Aff - Purified
Reactivity Hu, Rt
Applications C, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide: IKELHHFRILGEEQYN, corresponding to amino acids 298-313 of Human Parkin. This sequence is completely conserved between human, mouse and rat.
Application IHC-Fr, WB
Background Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.
Concentration 1 mg/ml
General Readings General / background references:Fallon L et al. Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J Biol Chem 277:486-91 (2002). PubMed PMID: 11679592
Tanaka K et al. Parkin is linked to the ubiquitin pathway. J Mol Med 79:482-94 (2001). PubMed PMID: 11692161
Chung KK et al. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med 7:1144-50 (2001). PubMed PMID: 11590439
Immunogen affinity purified
Buffer System:
Constituents: PBS, 1mg/ml BSA
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human and Rat. Not yet tested in other species.

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